Links between innate and adaptive immunity via type I interferon.
نویسندگان
چکیده
Type I interferon (IFN-alpha/beta) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-alpha/beta and undergo maturation in response to IFN-alpha/beta. Moreover, IFN-alpha/beta has been shown to potently enhance immune responses in vivo through the stimulation of dendritic cells. These findings indicate that IFN-alpha/beta serves as a signal linking innate and adaptive immunity.
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ورودعنوان ژورنال:
- Current opinion in immunology
دوره 14 4 شماره
صفحات -
تاریخ انتشار 2002